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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-NURR1 (NR4A2)-XCT0135908
XCT0135908

Chemical Structure : XCT0135908

CAS No.: 300837-31-4

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XCT0135908 (BRF001, XCT 0135908)

货号: PC-20774Not For Human Use, Lab Use Only.

XCT0135908 (BRF001) is a highly selective activator of Nurr1-RXR heterodimers, stimulates dopamine (DA) neuron survival.

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25 mg ￥7980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

XCT0135908 (BRF001) is a highly selective activator of Nurr1-RXR heterodimers, stimulates dopamine (DA) neuron survival.
XCT0135908 (1 uM) is highly selective in activation of heterodimers formed between Gal4-Nurr1 and cotransfected RXR in African green monkey CV-1 cells.|
XCT0135908 is strictly selective for RXR/Nurr1 heterodimers at 1 uM.
The RXR antagonist LG1208 completely abolished activation by XCT0135908.

物理化学性质&存储条件

分子量 345.40
分子式 C21H19N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(O)C1=CC=C(NC2=NC(C3=CC=CC=C3)=NC(C)=C2CC=C)C=C1

参考文献

1. Wallen-Mackenzie A, et al. Genes Dev. 2003 Dec 15;17(24):3036-47.

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