X5050 | REST inhibitor | Probechem Biochemicals

Chemical Structure : X5050

CAS No.: 2404756-81-4

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X5050 (X 5050)

货号: PC-72525Not For Human Use, Lab Use Only.

X5050 (X-5050) is a small molecule that inhibits REST silencing in a RE1-dependent manner, targeted REST degradation.

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5 mg	￥2480	In stock
10 mg	￥3980	In stock
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100 mg		Get quote

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生物&药学活性

X5050 (X-5050) is a small molecule that inhibits REST silencing in a RE1-dependent manner, targeted REST degradation.
X5050 reduce REST protein levels in cells at a concentration of the 50-100 μM, leading to a 50% REST reduction.
X5050 upregulated neuronal genes targeted by REST in wild-type neural cells, as well as in human induced pluripotent stem cells derived from a Huntington disease (HD) patient.
X5050 increased the expressions of BDNF and several other REST-regulated genes in the prefrontal cortex of mice with quinolinate-induced striatal lesions.

物理化学性质&存储条件

分子量	309.325
分子式	C17H15N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Benzimidazole-6-carboxamide, 2-(2-hydroxyphenyl)-N-(2-propen-1-yloxy)-

参考文献

1. Charbord J, et al. Stem Cells. 2013 Sep;31(9):1816-28.

2. Brenda Medellin, et al. J Med Chem. 2022 Jan 13;65(1):507-519.

X5050 (X 5050)

生物&药学活性

物理化学性质&存储条件

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X5050 (X 5050)

生物&药学活性

物理化学性质&存储条件

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