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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-X20404
X20404

Chemical Structure : X20404

CAS No.:

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X20404 (X-20404)

货号: PC-22093Not For Human Use, Lab Use Only.

X20404 is a small molecule inhibitor of the thioesterase activity of Mtb polyketide synthase 13 (Pks13) with IC50 of 0.4 uM in the Pks13-TE enzyme assay.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

X20404 is a small molecule inhibitor of the thioesterase activity of Mtb polyketide synthase 13 (Pks13) with IC50 of 0.4 uM in the Pks13-TE enzyme assay.
X20404 has a favorable pharmacokinetic profile and demonstrated efficacy in an acute mouse model of tuberculosis (TB) infection.

物理化学性质&存储条件

分子量 457.53
分子式 C26H27N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(2-(4-(6-(2,5-dimethoxyphenyl)pyridin-3-yl)-1H-1,2,3-triazol-1-yl)ethyl)-N,N-dimethylbenzamide

参考文献

1. Krieger IV, et al. ACS Infect Dis. 2024 Apr 5. doi: 10.1021/acsinfecdis.3c00592.

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