Withaferin A

Chemical Structure : Withaferin A

CAS No.: 5119-48-2

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货号: PC-62155Not For Human Use, Lab Use Only.

Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity, potently inhibits NF-κB activation by preventing the TNF-induced activation of IKKβ via a thioalkylation-sensitive redox mechanism.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg	￥7580	In stock
100 mg		Get quote

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生物&药学活性

Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity, potently inhibits NF-κB activation by preventing the TNF-induced activation of IKKβ via a thioalkylation-sensitive redox mechanism.
Withaferin A potently inhibits the chymotrypsin-like activity of a purified rabbit 20S proteasome (IC50=4.5 uM) and 26S proteasome in human prostate cancer cultures (at 5-10 uM) and xenografts (4-8 mg/kg/day), inhibits cell proliferation in HUVECs (IC50 =12 nM).

物理化学性质&存储条件

分子量	470.6
分子式	C28H38O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone

参考文献

1. Falsey RR, et al. Nat Chem Biol. 2006 Jan;2(1):33-8.

2. Kaileh M, et al. J Biol Chem. 2007 Feb 16;282(7):4253-64.

3. Yang H, et al. Mol Pharmacol. 2007 Feb;71(2):426-37.

4. Mohan R, et al. Angiogenesis. 2004;7(2):115-22.

Withaferin A

生物&药学活性

物理化学性质&存储条件

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Withaferin A

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