Wiskostatin

Chemical Structure : Wiskostatin

CAS No.: 253449-04-6

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货号: PC-23091Not For Human Use, Lab Use Only.

Wiskostatin is a specific, cell-permeable chemical inhibitor of the neural Wiskott-Aldrich syndrome protein (N-WASP), inhibits N-WASP-mediated actin polymerization.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
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生物&药学活性

Wiskostatin is a specific, cell-permeable chemical inhibitor of the neural Wiskott-Aldrich syndrome protein (N-WASP), inhibits N-WASP-mediated actin polymerization.
Wiskostatin interacts with a cleft in the regulatory GTPase-binding domain (GBD) of WASP in the solution structure of the complex.
Wiskostatin blocks N-WASP activity by stabilizing its autoinhibited conformation, thus leading to a significant decrease in the rate of actin polymerization.

物理化学性质&存储条件

分子量	426.15
分子式	C17H18Br2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(dimethylamino)propan-2-ol

参考文献

1. Peterson JR, et al. Nat Struct Mol Biol. 2004 Aug;11(8):747-55.

2. Guerriero CJ, et al. Am J Physiol Cell Physiol. 2007 Apr;292(4):C1562-6.

3. Ivanov AI, et al. Mol Biol Cell. 2005 Jun;16(6):2636-50.

Wiskostatin

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Wiskostatin

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