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首页-小分子抑制剂&激动剂-Epigenetics-Histone Acetyltransferase (HAT)-Windorphen
Windorphen

Chemical Structure : Windorphen

CAS No.: 19881-70-0

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Windorphen

货号: PC-70121Not For Human Use, Lab Use Only.

Windorphen is a potent, selective inhibitor of p300 histone acetyltransferase (IC50=4.2 uM).

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10 mg ￥1580 In stock
25 mg ￥2580 In stock
50 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Windorphen is a potent, selective inhibitor of p300 histone acetyltransferase (IC50=4.2 uM).
Windorphen displays >10-fold selectivity over other histone acetyltransferases.
Windorphen inhibits Wnt3a-inducible TOPFLASH-luciferase activity with IC50 of 1.5 uM, exhibits remarkable specificity toward β-catenin-1 function and selectively blocks the Wnt signal required for ventral development.
Windorphen robustly and selectively kills cancer cells that harbor Wnt-activating mutations.

物理化学性质&存储条件

分子量 302.75
分子式 C17H15ClO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-3-chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde

参考文献

1. Hao J, et al. Cell Rep. 2013 Sep 12;4(5):898-904.

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