Wedelolactone

Chemical Structure : Wedelolactone

CAS No.: 524-12-9

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货号: PC-20897Not For Human Use, Lab Use Only.

Wedelolactone is a small molecule inhibitor of LPS-induced caspase-11 expression by directly inhibits the IKK Complex, also inhibits 5-lipoxygenase with IC50 of 2.5 uM.

规格	价格	库存
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg	￥5280	In stock
1 g		Get quote

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生物&药学活性

Wedelolactone is a small molecule inhibitor of LPS-induced caspase-11 expression by directly inhibits the IKK Complex, also inhibits 5-lipoxygenase with IC50 of 2.5 uM.
Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. enhances bone marrow mesenchymal stem cells (BMSC) differentiation towards osteoblasts.
Wedelolactone inhibits GSK3β activity and increases β-catenin and runx2 nuclear accumulation in BMSC, and inhibits the effect of RANKL.
Wedelolactone decreases bone volumn and trabecular number at the femur after ovarietomy, and prevents the VOX-induced bone loss.

物理化学性质&存储条件

分子量	314.25
分子式	C16H10O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,8,9-trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one

参考文献

1. Kobori M, et al. Cell Death Differ. 2004 Jan;11(1):123-30.

2. Liu YQ, et al. Sci Rep. 2016 Aug 25;6:32260.

Wedelolactone

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Wedelolactone

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