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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Anaplastic Lymphoma Kinase (ALK)-WZH-15-125
WZH-15-125

Chemical Structure : WZH-15-125

CAS No.: 2845188-22-7

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WZH-15-125

货号: PC-24806Not For Human Use, Lab Use Only.

WZH-15-125 is a potent, selective ALK inhibitor with actiivty against Ba/F3 cells expressing ALK mutations (ALK WT, IC50<1.6 nM; ALK L1196 M, IC50=16.2 nM), overcomes resistance to all generations of ALK TKIs.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

WZH-15-125 is a potent, selective ALK inhibitor with actiivty against Ba/F3 cells expressing ALK mutations (ALK WT, IC50<1.6 nM; ALK L1196 M, IC50=16.2 nM), overcomes resistance to all generations of ALK TKIs.

物理化学性质&存储条件

分子量 745.74
分子式 C33H45BrN8O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(6-((5-bromo-2-((5-ethyl-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-N-methylmethanesulfonamide

参考文献

1. Gao F, et al. Eur J Med Chem. 2025 Jun 2;296:117835.

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