WZ811 | CXCR4 inhibitor | Probechem Biochemicals

Chemical Structure : WZ811

CAS No.: 55778-02-4

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WZ811 (WZ-811)

货号: PC-38725Not For Human Use, Lab Use Only.

WZ811 is a nonpeptidic, small molecule antagonist of CXCR4 with EC50 of 0.3 nM affinity binding assays, suppresses cancer cells aggressive in a variety of cancers.

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25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
1 g		Get quote

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生物&药学活性

WZ811 is a nonpeptidic, small molecule antagonist of CXCR4 with EC50 of 0.3 nM affinity binding assays, suppresses cancer cells aggressive in a variety of cancers.
WZ811 potently inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP levels (EC50=1.2 nM) and SDF-1 induced Matrigel invasion (EC50=5.2 nM).
WZ811 decreases chronic lymphocytic leukemia cells cell viability, colony formation, migration, and survival with cell cycle arrest and higher sensitivity to docetaxel in vitro.
WZ811 exhibits tumor growth inhibition in mouse xenograft models developed with human leukemia cells.

物理化学性质&存储条件

分子量	290.36
分子式	C18H18N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

参考文献

1. Zhan W, et al. J Med Chem. 2007 Nov 15;50(23):5655-64.

2. Kawatkar SP, et al. Exp Biol Med (Maywood). 2011 Jul;236(7):844-50.

3. Li SH, et al. Am J Transl Res. 2016 Sep 15;8(9):3812-3821.

WZ811 (WZ-811)

生物&药学活性

物理化学性质&存储条件

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WZ811 (WZ-811)

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