WZ4003 | NUAK inhibitor | Probechem Biochemicals

Chemical Structure : WZ4003

CAS No.: 1214265-58-3

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WZ4003 (WZ-4003, WZ 4003)

货号: PC-21279Not For Human Use, Lab Use Only.

WZ4003 is a potent, highly specific protein kinase inhibitor of NUAK kinase with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

WZ4003 is a potent, highly specific protein kinase inhibitor of NUAK kinase with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.
WZ4003 displays extreme selectivity and does not significantly inhibit the activity of 139 other kinases including ten AMPK family members.
WZ4003 inhibits the phosphorylation of the only well-characterized substrate, MYPT1 (myosin phosphate-targeting subunit 1) that is phosphorylated by NUAK1 at Ser(445).
WZ4003 significantly inhibits migration in a wound-healing assay to a similar extent as NUAK1-knockout in MEFs (mouse embryonic fibroblasts), also inhibit proliferation of MEFs to the same extent as NUAK1 knockout and U2OS cells to the same extent as NUAK1 shRNA knockdown.

物理化学性质&存储条件

分子量	497.00
分子式	C25H29ClN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide

参考文献

1. Banerjee S, et al. Biochem J. 2014 Jan 1;457(1):215-25.

WZ4003 (WZ-4003, WZ 4003)

生物&药学活性

物理化学性质&存储条件

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WZ4003 (WZ-4003, WZ 4003)

生物&药学活性

物理化学性质&存储条件

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