WZ-4-49-8 |CAS:1125594-27-5 Probechem Biochemicals

Chemical Structure : WZ-4-49-8

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WZ-4-49-8

货号: PC-61638Not For Human Use, Lab Use Only.

WZ-4-49-8 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 67 nM.

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生物&药学活性

WZ-4-49-8 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 67 nM.
WZ-4-49-8 displays an exceptional selectivity profile with a selectivity score of only 0.027 in a panel of 442 kinases.
WZ-4-49-8 inhibits c-Fes-L145P autophosphorylation and microtubule association in at least a subset of cells, and potently inhibits c-Fes-L145P-mediated soft-agar colony growth.
WZ-4-49-8 dramatically inhibits osteoclast differentiation in RAW 264.7 macrophage cell line.

物理化学性质&存储条件

分子量	618.801
分子式	C32H42N8O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N6-(4-[1,4'-Bipiperidin]-1'-yl-2-ethoxyphenyl)-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

参考文献

1. Hellwig S, et al. Chem Biol. 2012 Apr 20;19(4):529-40.

2. Weir MC, et al. PLoS One. 2017 Jul 20;12(7):e0181178.

WZ-4-49-8

生物&药学活性

物理化学性质&存储条件

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WZ-4-49-8

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