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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Proteasome-WZ-1831
WZ-1831

Chemical Structure : WZ-1831

CAS No.: 2892822-24-9

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WZ-1831 (WZ1831)

货号: PC-49521Not For Human Use, Lab Use Only.

WZ-1831 is a potent and highly selective inhibitor of human constitutive proteasome chymotryptic activity (β5c) with IC50 of 10 nM, >500-fold selectivity over β5i (IC50=7.1 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    WZ-1831 is a potent and highly selective inhibitor of human constitutive proteasome chymotryptic activity (β5c) with IC50 of 10 nM, >500-fold selectivity over β5i (IC50=7.1 uM).
    WZ-1831 enters the cells to engage the proteasome target, potently and selectively kills multiple myeloma cells, and does so by synergizing with a β5i-selective inhibitor.

    物理化学性质&存储条件

    分子量 492.34
    分子式 C25H29BN4O6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-(3-((2-(2-(1H-indol-3-yl)-2-oxoacetamido)-4-(tert-butylamino)-4-oxobutanamido)methyl)phenyl)boronic acid

    参考文献

    1. Wenhu Zhan, et al. J Med Chem. 2023 Jan 6. doi: 10.1021/acs.jmedchem.2c00733.

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