WYE-151650 | JAK3 inhibitor | Probechem Biochemicals

Chemical Structure : WYE-151650

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WYE-151650 (WYE151650)

货号: PC-62971Not For Human Use, Lab Use Only.

WYE-151650 is a potent, selective JAK3 inhibitor with IC50 of 0.8 nM, displays 36-, 14-, and 34-fold selectivity against JAK-1, JAK-2, and Tyk-2, respectively.

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生物&药学活性

WYE-151650 is a potent, selective JAK3 inhibitor with IC50 of 0.8 nM, displays 36-, 14-, and 34-fold selectivity against JAK-1, JAK-2, and Tyk-2, respectively.
WYE-151650 inhibits IL-2-induced proliferation in human PBMC blasts with IC50 of 50 nM, inhibits IL-2-induced STAT-5 phosphorylation of lymphocytes.
WYE-151650 exhibits 10-29-fold less activity against JAK-3-independent IL-6- or GM-CSF-induced STAT phosphorylation.
WYE-151650 inhibits JAK-3-mediated IL-2-induced IFN-gamma production and decreases the natural killer cell population in mice, shows efficacy in mouse DTH and CIA models.

物理化学性质&存储条件

分子量	435.487
分子式	C26H21N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[8,9-Dihydro-7-methyl-8-oxo-9-[(1R,4R)-1,2,3,4-tetrahydro-4-hydroxy-1-naphthalenyl]-7H-purin-2-yl]-1H-benzimidazole-6-carbonitrile

参考文献

1. Lin TH, et al. Arthritis Rheum. 2010 Aug;62(8):2283-93.

WYE-151650 (WYE151650)

生物&药学活性

物理化学性质&存储条件

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WYE-151650 (WYE151650)

生物&药学活性

物理化学性质&存储条件

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