WYE-125132 |CAS:1144068-46-1 Probechem Biochemicals

Chemical Structure : WYE-125132

CAS No.: 1144068-46-1

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WYE-125132 (WYE-132;WYE125132)

货号: PC-42157Not For Human Use, Lab Use Only.

A potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM.

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5 mg	￥980	In stock
10 mg	￥1380	In stock
25 mg	￥2280	In stock
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生物&药学活性

WYE-125132 (WYE-132) is a potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM.
WYE-125132 dispalys high selectivity (>5,000-fold) over PI3Ks, the PI3K-related kinases hSMG1 and ATR, and a panel of 230 protein kinases.
WYE-125132 inhibits mTORC1-dependent phosphorylation of S6K(T389) and mTORC2-dependent phosphorylation of AKT(S473), inhibits cancer cell proliferation, cell cycle progression, and induces apoptosis.
WYE-125132 shows potent single-agent antitumor activity against multiple cancer models.

物理化学性质&存储条件

分子量	519.5954
分子式	C27H33N7O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 62 mg/mL
Chemical Name/SMILES	Urea, N-[4-[1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methyl-

参考文献

1. Yu K, et al. Cancer Res. 2010 Jan 15;70(2):621-31.

WYE-125132 (WYE-132;WYE125132)

生物&药学活性

物理化学性质&存储条件

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WYE-125132 (WYE-132;WYE125132)

生物&药学活性

物理化学性质&存储条件

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