WYC-209 |CAS:2131803-90-0 Probechem Biochemicals

Chemical Structure : WYC-209

CAS No.: 2131803-90-0

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WYC-209 (WYC209)

货号: PC-63510Not For Human Use, Lab Use Only.

WYC-209 is a novel synthetic retinoid that inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs) with IC50 of 0.19 uM, targets retinoic acid receptor (RAR).

规格	价格	库存
10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥3180	In stock
100 mg	￥5280	In stock
250 mg		Get quote
1 g		Get quote

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生物&药学活性

WYC-209 is a novel synthetic retinoid that inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs) with IC50 of 0.19 uM, targets retinoic acid receptor (RAR).
WYC-209 also inhibits proliferation of TRCs of human melanoma, lung cancer, ovarian cancer, and breast cancer in culture.
WYC-209 abrogates lung metastases of melanoma TRCs in immune-competent wild-type C57BL/6 mice at 0.22 mg/kg without showing apparent toxicity.
WYC-209 induces TRCs apoptosis primarily via the caspase 3 pathway, RAR siRNAs or antagonists can block or reduce the inhibitory effect of WYC-209.

物理化学性质&存储条件

分子量	368.451
分子式	C20H20N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 2-((4,4-dimethyl-1-oxidothiochroman-6-yl)ethynyl)pyrimidine-5-carboxylate

参考文献

1. Chen J, et al. Nat Commun. 2018 Apr 11;9(1):1406.

WYC-209 (WYC209)

生物&药学活性

物理化学性质&存储条件

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WYC-209 (WYC209)

生物&药学活性

物理化学性质&存储条件

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