WX-554 | Probechem Biochemicals

Chemical Structure : WX-554

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WX-554 (WX554)

货号: PC-63100Not For Human Use, Lab Use Only.

WX-554 is an oral, small molecule allosteric inhibitor targeting mitogen-activated protein kinase kinase (MEK1 and MEK2) with an estimated IC50 of 4.7 and 10.7 nM, respectively.

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生物&药学活性

WX-554 is an oral, small molecule allosteric inhibitor targeting mitogen-activated protein kinase kinase (MEK1 and MEK2) with an estimated IC50 of 4.7 and 10.7 nM, respectively; exhibits marked synergistic growth inhibition in vitro, which is associated with increased cytotoxicity and enhanced inhibition of ERK and S6 phosphorylation.

Solid Tumors

Phase 1 Discontinued

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Jamieson D, et al. Eur J Cancer. 2016 Nov;68:1-10.

2. Haagensen EJ, et al. Cancer Chemother Pharmacol. 2016 Dec;78(6):1269-1281.

WX-554 (WX554)

生物&药学活性

物理化学性质&存储条件

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WX-554 (WX554)

生物&药学活性

物理化学性质&存储条件

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