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WWL113

Chemical Structure : WWL113

CAS No.: 947669-86-5

WWL113 (WWL 113)

货号: PC-62253Not For Human Use, Lab Use Only.

WWL113 is a potent inhibitor of Carboxylesterase Ces3 and Ces1f by competitive ABPP of enzymes recombinantly expressed in HEK293T cells (IC50 value of 0.1 uM for each enzyme).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

WWL113 is a potent inhibitor of Carboxylesterase Ces3 and Ces1f by competitive ABPP of enzymes recombinantly expressed in HEK293T cells (IC50 value of 0.1 uM for each enzyme).
WWL113 doses not inhibit any of the other serine hydrolases.
WWL113 reduces the activity signals for ABHD6, promotes lipid storage in cultured adipocytes and prevents basal lipolysis.
WWL113 ameliorates obesity-diabetes in mice.

物理化学性质&存储条件

分子量 466.537
分子式 C29H26N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Ethyl-4'-((methyl(3-(pyridin-4-yl)benzyl)carbamoyl)oxy)-[1,1'-biphenyl]-4-carboxylate

参考文献

1. Dominguez E, et al. Nat Chem Biol. 2014 Feb;10(2):113-21.

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