WW-III-55 | D3R agonist | Probechem Biochemicals

Chemical Structure : WW-III-55

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WW-III-55 (Dopamine D3 receptor agonist)

货号: PC-38470Not For Human Use, Lab Use Only.

WW-III-55 is a high-affinity, selective dopamine D3 receptor (D3R) partial agonist with Ki value of 20 nM, exhibits >800-fold binding selectivity for D3R compared with the D2R.

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生物&药学活性

WW-III-55 is a high-affinity, selective dopamine D3 receptor (D3R) partial agonist with Ki value of 20 nM, exhibits >800-fold binding selectivity for D3R compared with the D2R.
WW-III-55 (0-5.6 mg/kg) reduced cocaine self-administration, also reduced responding for sucrose and locomotor activity.
WW-III-55 attenuated yawning induced by low doses of 7-OH-DPAT (a D3R-mediated behavior).
WW-III-55 (10 mg/kg) inhibited the head twitch response (HTR) by 95% in DBA/2J mice.

物理化学性质&存储条件

分子量	449.613
分子式	C26H31N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(4-(4-methoxyphenyl)piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamide

参考文献

1. Timothy H C Cheung, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):410-23.

2. Rangel-Barajas C, et al. Neuropharmacology. 2015 Jun;93:179-90.

WW-III-55 (Dopamine D3 receptor agonist)

生物&药学活性

物理化学性质&存储条件

参考文献

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WW-III-55 (Dopamine D3 receptor agonist)

生物&药学活性

物理化学性质&存储条件

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