WT161 | HDAC6 inhibitor | Probechem Biochemicals

Chemical Structure : WT161

CAS No.: 1206731-57-8

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WT161 (WT 161, WT-161)

货号: PC-70299Not For Human Use, Lab Use Only.

WT161 (WT-161) is a potent, selective, and bioavailable HDAC6 inhibitor with IC50 0.4 nM.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

WT161 (WT-161) is a potent, selective, and bioavailable HDAC6 inhibitor with IC50 0.4 nM.
WT161 displays >20-fold selectivity over HDAC1/2/3/8.
WT161 selectively inhibits HDAC6 and dramatically increases levels of acetylated α-tubulin with little effect on global lysine acetylation in cells.
WT161 reversibly and rapidly induces the accumulation of Ac-α-tubulin in MM cell lines, displays synergism with both BTZ and CFZ, caspase activation and apoptosis.
WT161 demonstrates a significant antitumor effect in human MM cell xenograft mouse model combined with BTZ.

物理化学性质&存储条件

分子量	458.55
分子式	C27H30N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Octanoic acid, 8-(hydroxyamino)-8-oxo-, 2-[[4-(diphenylamino)phenyl]methylene]hydrazide

参考文献

1. Hideshima T, et al. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13162-13167.

2. Hideshima T, et al. Oncotarget. 2017 Jul 5. doi: 10.18632/oncotarget.19019.

WT161 (WT 161, WT-161)

生物&药学活性

物理化学性质&存储条件

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WT161 (WT 161, WT-161)

生物&药学活性

物理化学性质&存储条件

参考文献

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