WS6 | PA2G4 inhibitor | Probechem Biochemicals

Chemical Structure : WS6

CAS No.: 1421227-53-3

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WS6 (WS-6,PA2G4 inhibitor)

货号: PC-43043Not For Human Use, Lab Use Only.

WS6 is a small molecule that can induce proliferation of β cells with EC50 of 0.28 uM, also is a selective proliferation-associated 2G4 (PA2G4) inhibitor, interferes with PA2G4-MYCN binding.

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10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

WS6 is a small molecule that can induce proliferation of β cells with EC50 of 0.28 uM, also is a selective proliferation-associated 2G4 (PA2G4) inhibitor, interferes with PA2G4-MYCN binding.
WS6 promotes β cell growth in vivo, increasing β cell mass and normalizing blood glucose in the RIP-DTA mouse model of β cell ablation.
WS6 acts by inhibiting IKKε and blocking the ability of EBP1 to suppress E2F-medtiated transcription;.
WS6 also stimulates α cell proliferation in human pancreatic islets.
WS6 depletes EVI1 and MYC signaling and blocks 3q26 AML in vivo

物理化学性质&存储条件

分子量	568.59
分子式	C29H31F3N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzeneacetamide, 4-[[6-[(cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-

参考文献

1. Swoboda JG, et al. ACS Chem Biol. 2013 Jul 19;8(7):1407-11.

2. Shen W, et al. J Am Chem Soc. 2013 Feb 6; 135(5):1669-72.

WS6 (WS-6,PA2G4 inhibitor)

生物&药学活性

物理化学性质&存储条件

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WS6 (WS-6,PA2G4 inhibitor)

生物&药学活性

物理化学性质&存储条件

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