WS-383 hydrochloride |CAS:2247544-02-9 Probechem Biochemicals

Chemical Structure : WS-383 hydrochloride

CAS No.: 2247544-02-9

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WS-383 hydrochloride (WS383;WS 383)

货号: PC-36110Not For Human Use, Lab Use Only.

WS-383 hydrochloride (WS383) is a highly potent, selective, and cellular active inhibitor of DCN1-UBC12 interaction with IC50 of 11 nM.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

WS-383 hydrochloride (WS383) is a highly potent, selective, and cellular active inhibitor of DCN1-UBC12 interaction with IC50 of 11 nM.
WS-383 inhibits Cul3/1 neddylation selectively over other cullins and also induces accumulation of p21, p27 and NRF2.
WS-383 exhibits cellular target engagement to DCN1 in MGC-803 cells, enhances the thermal stability of cellular DCN1 protein even at 1 uM.

物理化学性质&存储条件

分子量	498.449
分子式	C18H21Cl2N9S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-((2-((4-Chlorobenzyl)thio)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)thio )-1H-tetrazol-1-yl)-N,N-dimethylethan-1-amine hydrochloride

参考文献

1. Wang S, et al. J Med Chem. 2019 Feb 25. doi: 10.1021/acs.jmedchem.9b00113.

WS-383 hydrochloride (WS383;WS 383)

生物&药学活性

物理化学性质&存储条件

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WS-383 hydrochloride (WS383;WS 383)

生物&药学活性

物理化学性质&存储条件

参考文献

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