WS-12 | TRPM8 agonist | Probechem Biochemicals

Chemical Structure : WS-12

CAS No.: 68489-09-8

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WS-12 (Acoltremon, AR-15512, AVX-012, TRPM8 agonist WS12)

货号: PC-60786Not For Human Use, Lab Use Only.

WS-12 (Acoltremon, AR-15512, AVX-012) is a potent, selective TRPM8 agonist with EC50 of 12 uM, a cooling agent.

规格	价格	库存
1 mg (Free Sample)	￥280	In stock
5 mg	￥880	In stock
10 mg	￥1280	In stock
50 mg	￥2880	In stock
100 mg	￥4480	In stock
250 mg		Get quote

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生物&药学活性

WS-12 (Acoltremon, AR-15512, AVX-012) is a potent, selective TRPM8 agonist with EC50 of 12 uM, a cooling agent.
WS-12 displays higher potency and efficacy compared to menthol (EC50=193 uM), does activates thermo-sensitive TRP ion channel including TRPV1, TRPV2, TRPV3, TRPV4 and TRPA1 at 1 mM.
WS-12 accelerates skin permeability barrier recovery, also reduces epidermal proliferation associated with barrier disruption.

物理化学性质&存储条件

分子量	289.41
分子式	C18H27NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2S)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide

参考文献

1. Sherkheli MA, et al. J Pharm Pharm Sci. 2010;13(2):242-53.

2. Anand U, et al. Mol Pain. 2010 Nov 24;6:82.

3. Denda M, et al. Exp Dermatol. 2010 Sep;19(9):791-5.

4. Gardiner JC, et al. Eur J Pharmacol. 2014 Oct 5;740:398-409.

WS-12 (Acoltremon, AR-15512, AVX-012, TRPM8 agonist WS12)

生物&药学活性

物理化学性质&存储条件

参考文献

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WS-12 (Acoltremon, AR-15512, AVX-012, TRPM8 agonist WS12)

生物&药学活性

物理化学性质&存储条件

参考文献

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