WRW4 | FPR2 inhibitor | Probechem Biochemicals

Chemical Structure : WRW4

CAS No.: 878557-55-2

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WRW4 (WRWWWW, Trp-Arg-Trp-Trp-Trp-Trp)

货号: PC-20391Not For Human Use, Lab Use Only.

WRW4 (Trp-Arg-Trp-Trp-Trp-Trp) is a selective antagonist of formyl peptide receptor 2 (FPR2, FPRL1) signaling, inhibits WKYMVm binding to FPR2 with IC50 of 0.23 uM.

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生物&药学活性

WRW4 (Trp-Arg-Trp-Trp-Trp-Trp) is a selective antagonist of formyl peptide receptor 2 (FPR2, FPRL1) signaling, inhibits WKYMVm binding to FPR2 with IC50 of 0.23 uM.
WRW4 inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide.
WRW4 also inhibits FPR2-mediated signaling in human neutrophils.
WRW4 blocks chemotactic migration and superoxide generation by amyloid β42 peptide.

物理化学性质&存储条件

分子量	1104.27
分子式	C61H65N15O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Tryptophyl-L-arginyl-L-tryptophyl-L-tryptophyl-L-tryptophyl-L-tryptophanamide

参考文献

1. Bae YS, et al. J Immunol. 2004 Jul 1;173(1):607-14.

2. Karlsson J, et al. Biochem Pharmacol. 2006 May 14;71(10):1488-96.

WRW4 (WRWWWW, Trp-Arg-Trp-Trp-Trp-Trp)

生物&药学活性

物理化学性质&存储条件

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WRW4 (WRWWWW, Trp-Arg-Trp-Trp-Trp-Trp)

生物&药学活性

物理化学性质&存储条件

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