WRG-28 | CAS: 1913291-02-7 Probechem Biochemicals

Chemical Structure : WRG-28

CAS No.: 1913291-02-7

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WRG-28 (DDR2 inhibitor WRG-28;WRG28)

货号: PC-35521Not For Human Use, Lab Use Only.

WRG-28 (DDR2 inhibitor WRG-28) is a potent, selective, allosteric inhibitor of discoidin domain receptor 2 (DDR2) with binding IC50 of 230 nM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

WRG-28 (DDR2 inhibitor WRG-28) is a potent, selective, allosteric inhibitor of discoidin domain receptor 2 (DDR2) with binding IC50 of 230 nM.
WRG-28 bluntsd collagen I-mediated DDR2 tyrosine phosphorylation, ERK activation, and SNAIL1 protein stabilization (IC50=286 nM) in HEK293 cells expressing DDR2, without effect on normal mammary epithelial MCF10A cells.
WRG-28 displays no activity against collagen I-induced tyrosine phosphorylation of the related DDR1 RTK in HEK293 cells.
WRG-28 inhibits DDR2-collagen interaction in an allosteric manner, inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs.

物理化学性质&存储条件

分子量	410.444
分子式	C21H18N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-ethyl-4-(((3-oxo-3H-phenoxazin-7-yl)oxy)methyl)benzenesulfonamide

参考文献

1. Grither WR, et al. Proc Natl Acad Sci U S A. 2018 Jul 30. pii: 201805020.

WRG-28 (DDR2 inhibitor WRG-28;WRG28)

生物&药学活性

物理化学性质&存储条件

参考文献

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WRG-28 (DDR2 inhibitor WRG-28;WRG28)

生物&药学活性

物理化学性质&存储条件

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