WR-S-462

Chemical Structure : WR-S-462

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货号: PC-25257Not For Human Use, Lab Use Only.

WR-S-462 is a highly potent and selective STAT3 inhibitor with SPR Kd of 58 nM, directly interferes with the STAT3-SH2 domain interaction.

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生物&药学活性

WR-S-462 is a highly potent and selective STAT3 inhibitor with SPR Kd of 58 nM, directly interferes with the STAT3-SH2 domain interaction.
WR-S-462 significantly disrupts STAT3 nuclear localization and inhibits STAT3 Y705 phosphorylation both in MDA-MB-231 and BT549 cells.
WR-S-462 exhibits little inhibitory effects on JAK1, JAK2, JAK3, EGFR, and SRC kinases, shows no discernible impact on the phosphorylation levels of JAK1, ERK1/2, AKT, STAT1, and STAT5.
WR-S-462 selectively inhibits the expression of p-STAT3Tyr705 and downstream target genes regulated by STAT3 in MDA-MB-231 cells.
WR-S-462 strongly suppresses the colony formation of TNBC cells.
WR-S-462 forcefully suppresses the migration and invasion of TNBC cells.
WR-S-462 promotes TNBC cell apoptosis, inhibits tumor growth in preclinical TNBC xenografts.

物理化学性质&存储条件

分子量	462.52
分子式	C24H22N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Cyano-2-(3-methoxybenzamido)-N-(2-methoxyphenyl)-4,7-dihydrothieno[2,3-c] pyridine-6(5H)-carboxamide

参考文献

1. Jin W, et al. Eur J Med Chem. 2025 Apr 5;287:117332.

WR-S-462

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物理化学性质&存储条件

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WR-S-462

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物理化学性质&存储条件

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