WP760 | Probechem Biochemicals

Chemical Structure : WP760

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WP760 (WP 760;WP-760)

货号: PC-61008Not For Human Use, Lab Use Only.

A bis-anthracycline and melanoma selective agent that demonstrates anti-melanoma activity at low nanomolar concentrations.

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生物&药学活性

WP760 is a bis-anthracycline and melanoma selective agent that demonstrates anti-melanoma activity at low nanomolar concentrations.
WP760 abrogates melanoma cell growth by transcription inhibition, p53 activation and IGF1R downregulation; inhibits melanoma cell proliferation (IC50 =1-99 nM), impaired clonogenic cell survival (100 nM), and inhibits spheroid growth (>300 nM), but does not induce double-stranded DNA breaks.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Olbryt M, et al. Invest New Drugs. 2017 Oct;35(5):545-555.

2. Zheng M, et al. Cancer Chemother Pharmacol. 2007 Oct;60(5):625-33.

WP760 (WP 760;WP-760)

生物&药学活性

物理化学性质&存储条件

参考文献

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WP760 (WP 760;WP-760)

生物&药学活性

物理化学性质&存储条件

参考文献

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