WP1130 |CAS:856243-80-6 Probechem Biochemicals

Chemical Structure : WP1130

CAS No.: 856243-80-6

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WP1130 (Degrasyn;WP 1130;WP-1130)

货号: PC-43444Not For Human Use, Lab Use Only.

WP1130 (Degrasyn) is a small molecule that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression (IC50=1.8 uM), also inhibits deubiquitinases and blocks autophagy.

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25 mg	￥1880	In stock
50 mg	￥2880	In stock
100 mg	￥4580	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

WP1130 (Degrasyn) is a small molecule that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression (IC50=1.8 uM), also inhibits deubiquitinases and blocks autophagy.
WP1130 reduces leukemic versus normal hematopoietic colony formation and strongly inhibits colony formation of cells derived from patients with T315I mutant Bcr/Abl-expressing CML in blast crisis.
WP1130 suppresses the growth of K562 heterotransplanted tumors as well as both wild-type Bcr/Abl and T315I mutant Bcr/Abl-expressing BaF/3 cells in vivo.
WP1130 acts as a partly selective DUB inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37, triggers aggresome formation and tumor cell apoptosis.

物理化学性质&存储条件

分子量	384.27
分子式	C19H18BrN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	2-Propenamide, 3-(6-bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-, (2E)-

参考文献

1. Bartholomeusz GA, et al. Blood. 2007 Apr 15;109(8):3470-8.

2. Bartholomeusz G, et al. Cancer Res. 2007 Apr 15;67(8):3912-8.

3. Kapuria V, et al. Cancer Res. 2010 Nov 15;70(22):9265-76.

4. Drießen S, et al. Autophagy. 2015;11(9):1458-70.

WP1130 (Degrasyn;WP 1130;WP-1130)

生物&药学活性

物理化学性质&存储条件

参考文献

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WP1130 (Degrasyn;WP 1130;WP-1130)

生物&药学活性

物理化学性质&存储条件

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