WP1066 | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : WP1066

CAS No.: 857064-38-1

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WP1066 (WP-1066)

货号: PC-73189Not For Human Use, Lab Use Only.

WP1066 is a potent, cell-active STAT3 pathway inhibitor, inhibits human malignant glioma U87-MG and U373-MG cells in vitro with IC50 of 5.6 and 3.7 uM.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1180	In stock
50 mg	￥1880	In stock
100 mg		Get quote

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生物&药学活性

WP1066 is a potent, cell-active STAT3 pathway inhibitor, inhibits human malignant glioma U87-MG and U373-MG cells in vitro with IC50 of 5.6 and 3.7 uM.
WP1066 activated Bax, suppressed the expression of c-myc, Bcl-XL and Mcl-1, and induced apoptosis.
WP1066 inhibited the growth of subcutaneous malignant glioma xenografts during the 30-day follow-up period via systemic intraperitoneal administration.
WP1066 inhibited the phosphorylation of JAK2 and also degraded JAK2 protein in AML cells, thereby blocking its downstream STAT and PI3K pathways.

物理化学性质&存储条件

分子量	356.22
分子式	C17H14BrN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide

参考文献

1. Iwamaru A, et al. Oncogene. 2007 Apr 12;26(17):2435-44.

2. Hussain SF, et al. Cancer Res. 2007 Oct 15;67(20):9630-6.

3. Ferrajoli A, et al. Cancer Res. 2007 Dec 1;67(23):11291-9.

4. Verstovsek S, et al. Clin Cancer Res. 2008 Feb 1;14(3):788-96.

WP1066 (WP-1066)

生物&药学活性

物理化学性质&存储条件

参考文献

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WP1066 (WP-1066)

生物&药学活性

物理化学性质&存储条件

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