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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-WNN2048-F004
WNN2048-F004

Chemical Structure : WNN2048-F004

CAS No.: 353257-76-8

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WNN2048-F004 (Compound 4a)

货号: PC-49668Not For Human Use, Lab Use Only.

WNN2048-F004 (Compound 4a) is a potent, covalent, nonpeptidomimetic SARS-CoV-2 main protease (Mpro) inhibitor with biochemical IC50 of 103 nM, covalently binds to the substrate-binding pocket (Cys145) of SARS-CoV-2 Mpro.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    WNN2048-F004 (Compound 4a) is a potent, covalent, nonpeptidomimetic SARS-CoV-2 main protease (Mpro) inhibitor with biochemical IC50 of 103 nM, covalently binds to the substrate-binding pocket (Cys145) of SARS-CoV-2 Mpro.
    WNN2048-F004 showed good anti-SARS-CoV-2 infection activity in cell culture with IC50 value of 21.3 µmol/L without cytotoxicity effect.

    物理化学性质&存储条件

    分子量 274.12
    分子式 C10H5Cl2NO2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-chloropyridin-3-yl 3-chlorothiophene-2-carboxylate

    参考文献

    1. Zang Y, et al. Protein Cell. 2022 Sep 28;14(1):17-27.

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