WNK inhibitor 11 (WNK-IN-11) |CAS:2123489-30-3 Probechem Biochemicals

Chemical Structure : WNK inhibitor 11

CAS No.: 2123489-30-3

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WNK inhibitor 11 (WNK-IN-11)

货号: PC-61064Not For Human Use, Lab Use Only.

WNK inhibitor 11 is a potent, selectiive and orally active inhibitor of WNK1 kinase with IC50 of 6 nM, 1,000-fold selectivity over WNK4 and 57-fold selectivity over WNK2.

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5 mg	￥1580	In stock
10 mg	￥2280	In stock
25 mg	￥3980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

WNK inhibitor 11 (WNK-IN-11) is a potent, selectiive and orally active inhibitor of WNK1 kinase with IC50 of 6 nM, 1,000-fold selectivity over WNK4 and 57-fold selectivity over WNK2.
WNK inhibitor 11 shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and FER kinase.
WNK inhibitor 11 reduces blood pressure in mice overexpressing human WNK1.
WNK inhibitor 11 induces diuresis, natriuresis and kaliuresis in spontaneously hypertensive rats.

物理化学性质&存储条件

分子量	462.393
分子式	C21H21Cl2N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5-chloro-2-(2-(methylamino)thiazol-4-yl)pyridin-4-yl)(4-(4-chlorobenzyl)piperazin-1-yl)methanone

参考文献

1. Yamada K, et al. ACS Chem Biol. 2016 Dec 16;11(12):3338-3346.

WNK inhibitor 11 (WNK-IN-11)

生物&药学活性

物理化学性质&存储条件

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WNK inhibitor 11 (WNK-IN-11)

生物&药学活性

物理化学性质&存储条件

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