WNK463 | WNK kinase inhibitor | Probechem Biochemicals

Chemical Structure : WNK463

CAS No.: 2012607-27-9

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WNK463 (WNK-463, WNK 463)

货号: PC-42214Not For Human Use, Lab Use Only.

WNK463 is the first, potent, selective, and orally bioavailable pan With-No-Lysine (WNK) Kinase catalytic activity inhibitor with IC50 of 5/1/6/9 nM for WNK1/2/3/4, respectively.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

WNK463 is the first, potent, selective, and orally bioavailable pan With-No-Lysine (WNK) Kinase catalytic activity inhibitor with IC50 of 5/1/6/9 nM for WNK1/2/3/4, respectively.
WNK463 shows >50% inhibition against only 2 out of 442 human kinases at 10 uM.
WNK463 affects blood pressure and body fluid and electro-lyte homeostasis in rodent models of hypertension.

物理化学性质&存储条件

分子量	463.4562
分子式	C21H24F3N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	1H-Imidazole-5-carboxamide, N-(1,1-dimethylethyl)-1-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl]-4-piperidinyl]-

参考文献

1. Yamada K, et al. Nat Chem Biol. 2016 Nov;12(11):896-898.

2. Zhang J, et al. Sci Signal. 2016 Oct 18;9(450):pe3.

WNK463 (WNK-463, WNK 463)

生物&药学活性

物理化学性质&存储条件

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WNK463 (WNK-463, WNK 463)

生物&药学活性

物理化学性质&存储条件

参考文献

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