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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-WMS-1410
WMS-1410

Chemical Structure : WMS-1410

CAS No.: 1253197-38-4

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WMS-1410 (WMS1410)

货号: PC-38728Not For Human Use, Lab Use Only.

WMS-1410 is a NR2B selective NMDA receptor antagonist with Ki value of 14 nM, antagonizes glutamate induced excitotoxicity with IC50 of 18.4 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    WMS-1410 is a NR2B selective NMDA receptor antagonist with Ki value of 14 nM, antagonizes glutamate induced excitotoxicity with IC50 of 18.4 nM.
    WMS-1410 displays excellent selectivity over more than 100 further relevant target proteins.
    WMS-1410 (100 mg/kg) shows dose dependent analgesic activity in the late neuropathic pain phase of the formalin assay in mice.

    物理化学性质&存储条件

    分子量 311.425
    分子式 C20H25NO2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(4-Phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

    参考文献

    1. Tewes B, et al. Bioorg Med Chem. 2010 Nov 15;18(22):8005-15.

    2. Gresch A, et al. J Pharmacol Exp Ther. 2021 Nov;379(3):235-244.

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