WMJ-J-09

Chemical Structure : WMJ-J-09

CAS No.: 2416914-29-7

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货号: PC-24736Not For Human Use, Lab Use Only.

WMJ-J-09 is a potent, hydroxamate based HDAC inhibitor, exhibits potent inhibitory activity against class I HDACs, including HDAC1 (IC50=7.5 nM), HDAC2 (IC50=21.3 nM), HDAC3 (IC50=18.4 nM), and HDAC8 (IC50=90.9 nM), also strongly inhibitsHDAC6 (class IIb) with IC50 of 3.9 nM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

WMJ-J-09 is a potent, hydroxamate based HDAC inhibitor, exhibits potent inhibitory activity against class I HDACs, including HDAC1 (IC50=7.5 nM), HDAC2 (IC50=21.3 nM), HDAC3 (IC50=18.4 nM), and HDAC8 (IC50=90.9 nM), also strongly inhibitsHDAC6 (class IIb) with IC50 of 3.9 nM.
WMJ-J-09 arrests the cell cycle and induced apoptosis in HCT116 cells.
WMJ-J-09 shows moderate inhibition toward HDAC4 (class IIa) with an IC50 of 8715.7 nM.
WMJ-J-09 significantly reduces the polymerized tubulin fraction through HDAC inhibition.
WMJ-J-09 caused HCT116 cell death may involve p21 elevation and survivin suppression.
WMJ-J-09 triggers LKB1-p38MAPK-p53 signaling pathway to increases p21 expression and survivin reduction, culminating in HCT116 cell death.
WMJ-J-09 induced survivin degradation.
WMJ-J-09 (20 mg/kg/day) inhibits growth of the HCT116 tumor xenograft, does not impact mouse body weight.

物理化学性质&存储条件

分子量	445.53
分子式	C22H27N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-hydroxy-N8-(1-(phenylsulfonyl)indolin-6-yl)octanediamide

参考文献

1. Yen CS, et al. Front Pharmacol. 2018 Mar 1;9:167.

2. Huang YH, et al. Sci Rep. 2025 Jun 4;15(1):19590.

WMJ-J-09

生物&药学活性

物理化学性质&存储条件

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WMJ-J-09

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