WM-S1-030

Chemical Structure : WM-S1-030

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货号: PC-21442Not For Human Use, Lab Use Only.

WM-S1-030 is a highly potent, specific inhibitor of recepteur d'origine nantais (RON kinase, MST1R) with IC50 of 0.39 nM in in vitro enzyme activity.

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生物&药学活性

WM-S1-030 is a highly potent, specific inhibitor of recepteur d'origine nantais (RON kinase, MST1R) with IC50 of 0.39 nM in in vitro enzyme activity.
WM-S1-030 inhibits the activity of Met family members and a few tyrosine kinases (TKs) (Axl, Flt4, Mer, and TRKC), with IC50 values < 10 nM.
WM-S1-030 is >100-fold selective for the TKs DDR2, Flt3, IGF1R, and ROS, and >1000-fold selective for all other kinases against a panel of kinases, except Fms, KDR and TrkA.
WM-S1-030 shows strong potency against colo320HSR cells, with IC50 values of 27.41 nM, 98.7 nM, and 137.2 nM, in cell lines expressing RONΔ160, RONΔ155, and RONΔ165, respectively, which is much more potent than BMS777607.
WM-S1-030 effectively inhibits the RON variants and exerts potent anticancer efﬁcacy in RON variant-positive colon cancer.
WM-S1-030 elicits notable antitumor immunity in anti-PD-1 resistant cell derived mouse model.

物理化学性质&存储条件

分子量	695.74
分子式	C37H31F2N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-ethoxy-N-(3-fluoro-4-((2-(5-(morpholinomethyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

参考文献

1. Joseph Kim, et al. Cell Death Differ. 2023 Nov 6. doi: 10.1038/s41418-023-01235-9.

WM-S1-030

生物&药学活性

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WM-S1-030

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