WM-3835 | KAT7 inhibitor | Probechem Biochemicals

Chemical Structure : WM-3835

CAS No.: 2229025-70-9

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WM-3835 (WM3835)

货号: PC-38289Not For Human Use, Lab Use Only.

WM-3835 (WM 3835) is a potent, high-specific, cell-permeable inhibitor of MYST acetyltransferase HBO1 (KAT7 or MYST2).

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

WM-3835 (WM 3835) is a potent, high-specific, cell-permeable inhibitor of MYST acetyltransferase HBO1 (KAT7 or MYST2).
WM-3835 showed increased potency against HBO1 compared to WM-1119.
Treatment of a diverse set of AML cell lines with WM-3835 resulted in a marked reduction in tumour-cell viability, with an excellent dose-response relationship between a reduction of levels of H3K14ac,.
Treatment of cells with WM-3835 phenocopied the molecular and cellular effects of genetic depletion of HBO1 by inducing apoptosis, a G0/G1 cell-cycle arrest, differentiation of human AML cells and transcriptional repression on HOXA9 and HOXA10.
Inhibition of HBO1 phenocopied our genetic data and showed efficacy in a broad range of human cell lines and primary AML cells from patients.

物理化学性质&存储条件

分子量	400.42
分子式	C20H17FN2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-3-hydroxybenzenesulfonohydrazide

参考文献

1. Laura MacPherson, et al. Nature. 2020 Jan;577(7789):266-270.

2. Yan-Yang Gao, et al. Theranostics. 2021 Mar 4;11(10):4599-4615.

WM-3835 (WM3835)

生物&药学活性

物理化学性质&存储条件

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WM-3835 (WM3835)

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