WM-1119 | KAT6A inhibitor | Probechem Biochemicals

Chemical Structure : WM-1119

CAS No.: 2055397-28-7

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WM-1119 (WM1119;WM 1119)

货号: PC-35580Not For Human Use, Lab Use Only.

WM-1119 (WM1119) is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with Kd of 2 nM, shows greate bioavailability and specificity for KAT6A than WM-8014.

规格	价格	库存
5 mg	￥480	In stock
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

WM-1119 (WM1119) is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with Kd of 2 nM, shows greate bioavailability and specificity for KAT6A than WM-8014.
WM-1119 displays 1,100-fold and 250-fold selectivity over KAT5 and KAT7, respectively; causes cell cycle arrest in G1 and senescence phenotype similar to WM-8014.
WM-1119 demonstrates growth inhibition assays in lymphoma cell line EMRK1184 (IC50=0.25 uM, 10-fold potency than WM-8014), increases levels of Cdkn2a and Cdkn2b mRNA and p16INK4a and p19ARF protein, as well as a delayed increase in Cdkn1a mRNA.
WM-1119 arrests lymphoma growth in vivo without effect on haematocrit, erythrocytes or platelet numbers.

物理化学性质&存储条件

分子量	389.377
分子式	C18H13F2N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzoic acid, 3-fluoro-5-(2-pyridinyl)-, 2-[(2-fluorophenyl)sulfonyl]hydrazide

参考文献

1. Baell JB, et al. Nature. 2018 Aug;560(7717):253-257.

WM-1119 (WM1119;WM 1119)

生物&药学活性

物理化学性质&存储条件

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WM-1119 (WM1119;WM 1119)

生物&药学活性

物理化学性质&存储条件

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