WKYMVm hexapeptide | pan-FPR agonist | Probechem Biochemicals

Chemical Structure : WKYMVm hexapeptide

CAS No.: 187986-17-0

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WKYMVm hexapeptide (Trp-Lys-Tyr-Val-D-Met)

货号: PC-72084Not For Human Use, Lab Use Only.

WKYMVm hexapeptide is a potent, selective, pan-agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM).

规格	价格	库存
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

WKYMVm hexapeptide is a potent, selective, pan-agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM).
WKYMVm induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils.
WKYMVm also promotes monocyte survival through a PKC-, PI3-kinase- and Akt-dependent pathway.

物理化学性质&存储条件

分子量	856.11
分子式	C41H61N9O7S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 Month
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-6-amino-2-((S)-2-amino-3-(1H-indol-3-yl)propanamido)-N-((5S,8S,11S,14S)-5-carbamoyl-15-(4-hydroxyphenyl)-8-isopropyl-11-(2-(methylthio)ethyl)-7,10,13-trioxo-2-thia-6,9,12-triazapentadecan-14-yl)hexanamide

参考文献

1. Francesca Wanda Rossi, et al. J Immunol. 2015 Jun 1;194(11):5161-73.

2. Park B, et al. J Cell Mol Med. 2021 Sep;25(18):8936-8946.

3. Hu J, et al. J Cell Mol Med. 2020 Jan;24(2):1893-1905.

WKYMVm hexapeptide (Trp-Lys-Tyr-Val-D-Met)

生物&药学活性

物理化学性质&存储条件

参考文献

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WKYMVm hexapeptide (Trp-Lys-Tyr-Val-D-Met)

生物&药学活性

物理化学性质&存储条件

参考文献

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