WK500B | BCL6 inhibitor | Probechem Biochemicals

Chemical Structure : WK500B

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WK500B (WK 500B)

货号: PC-38659Not For Human Use, Lab Use Only.

WK500B is an orally available small molecule BCL6 inhibitor with IC50 of 1.39 uM (HTFR), exhibits potent efficacy against DLBCL in vitro and in vivo.

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生物&药学活性

WK500B is an orally available small molecule BCL6 inhibitor with IC50 of 1.39 uM (HTFR), exhibits potent efficacy against DLBCL in vitro and in vivo.
WK500B engaged BCL6 inside cells, blocked BCL6 repression complexes, reactivated BCL6 target genes, killed DLBCL cells and caused apoptosis as well as cell cycle arrest.
WK500B inhibited germinal center (GC) formation and DLBCL tumour growth without toxic and side effects in animal models.
WK500B displayed strong efficacy and favourable pharmacokinetics and presented superior druggability.

物理化学性质&存储条件

分子量	500.376
分子式	C22H23BrFN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-bromo-N-(4-((2-((3S,5R)-3,5-dimethylpiperazin-1-yl)-5-fluoropyrimidin-4-yl)amino)phenyl)picolinamide

参考文献

1. Yajing Xing, et al. Cancer Lett. 2022 Mar 31;529:100-111.

WK500B (WK 500B)

生物&药学活性

物理化学性质&存储条件

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WK500B (WK 500B)

生物&药学活性

物理化学性质&存储条件

参考文献

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