WJH-C19

Chemical Structure : WJH-C19

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货号: PC-26020Not For Human Use, Lab Use Only.

WJH-C19 is a novel potent, selective RIPK1 inhibitor with IC50 of 5.7 nM, shows negligible PI3Kα and RIPK2/3.

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生物&药学活性

WJH-C19 is a novel potent, selective RIPK1 inhibitor with IC50 of 5.7 nM, shows negligible PI3Kα and RIPK2/3.
WJH-C19 suppressed the RIPK1/RIPK3/MLKL signaling axis, attenuating inflammatory responses.
WJH-C19 achieved robust efficacy in DSS-induced colitis and CFA-induced arthritis models, with favorable pharmacokinetics and no observable toxicity.

物理化学性质&存储条件

分子量	516.02
分子式	C27H22ClN5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-(4-Chlorophenyl)ethyl)-6-(2-(cyclopropanecarboxamido)benzo[d]thiazol-6-yl)imidazo[1,2-a]pyridine-3-carboxamide

参考文献

1. Wu D, et al. bioRxiv [Preprint]. 2025 Dec 16:2025.12.15.694265.

WJH-C19

生物&药学活性

物理化学性质&存储条件

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WJH-C19

生物&药学活性

物理化学性质&存储条件

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