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首页-小分子抑制剂&激动剂-Others-Other Targets-WJ460
WJ460

Chemical Structure : WJ460

CAS No.: 1415251-36-3

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WJ460 (WJ 460;WJ-460;Myoferlin inhibitor WJ460)

货号: PC-35673Not For Human Use, Lab Use Only.

WJ460 (Myoferlin inhibitor WJ460, WJ-460) is a small molecule targeting myoferlin (MYOF), exerts anti-metastatic activity in the nanomolar range in breast cancer cells with IC50 of 43.37 nM in MDA-MB-231 and 36.40 nM in BT549 cells.

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10 mg ￥2980 In stock
25 mg ￥4880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

WJ460 (Myoferlin inhibitor WJ460, WJ-460) is a small molecule targeting myoferlin (MYOF), exerts anti-metastatic activity in the nanomolar range in breast cancer cells with IC50 of 43.37 nM in MDA-MB-231 and 36.40 nM in BT549 cells.
WJ460 significantly suppresses capillary-like tube formation of human umbilical vein endothelial cells (HUVECs), diminishes the level of phospho-VEGFR-2 and total VEGFR-2 in spontaneous metastasis mouse model.
WJ460 abrogates breast cancer lung extravasation and colonization in vivo.
WJ460 directly targets MYOF, binds to MYOF C2 domain (C2D) with Kd of 1.33 uM, facilitates the dissociation of MYOF in Rab7-positive late endosomes, reverses highly metastatic mesenchymal-like breast cancer cells back to an epithelial state and attenuates the metastatic ability in other tumors.

物理化学性质&存储条件

分子量 460.592
分子式 C27H28N2O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(3-(2-methoxyphenyl)-4-oxothiazolidin-2-yl)-N-(4-phenylbutyl)benzamide

参考文献

1. Zhang T, et al. Nat Commun. 2018 Sep 13;9(1):3726.

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