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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aldose Reductase-WJ-39
WJ-39

Chemical Structure : WJ-39

CAS No.: 3009908-95-3

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WJ-39 (Darirestat potassium salt)

货号: PC-22474Not For Human Use, Lab Use Only.

WJ-39 (Darirestat potassium salt) is a small molecule aldose reductase (AR) inhibitor, does not affect AR protein expression, reduces oxidative stress by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.

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10 mg ￥5280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

WJ-39 (Darirestat potassium salt) is a small molecule aldose reductase (AR) inhibitor, does not affect AR protein expression, reduces oxidative stress by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
WJ-39 treatment ameliorated streptozotocin- (STZ-) induced renal inflammation in diabetic nephropathy (DN) rats.
WJ-39 suppressed the activation of the nuclear factor-kappa B (NF-κB) pathway and the nucleotide-binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome to reduce the secretion of inflammatory factors.
WJ-39 alleviated inflammation via the Nrf2 pathway in rat mesangial cells cultured under high glucose (HG) conditions.
WJ-39 treatment prevented renal fibrosis by suppressing the TGF-β1/Smad pathway in diabetic nephropathy (DN).
WJ-39 reduced oxidative stress in the kidneys of DN rats by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
WJ-39 ameliorates renal tubular injury in diabetic nephropathy by activating PINK1/Parkin signaling.

物理化学性质&存储条件

分子量 430.32
分子式 C19H14Cl2KNO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1(4H)-Quinolineacetic acid, 3-[(2,3-dichlorophenyl)methyl]-6-methoxy-4-oxo-, potassium salt (1:1)

参考文献

1. Yang L, et al. Eur J Pharmacol. 2024 Mar 15;967:176376.

2. Zhou X, et al. Oxid Med Cell Longev. 2020 May 30;2020:7950457.

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