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首页-小分子抑制剂&激动剂-GPCR-Neurokinin Receptor-WIN 62577
WIN 62577

Chemical Structure : WIN 62577

CAS No.: 144177-32-2

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WIN 62577 (WIN 62,577)

货号: PC-24029Not For Human Use, Lab Use Only.

WIN 62577 (WIN 62,577) is a selective antagonist of tachykinin NK1 receptor, also is an allosteric enhancer with micromolar potency at muscarinic M3 receptor, also is a highly efficacious inhibitor of main protease (Mpro) of SARS-CoV-2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

WIN 62577 (WIN 62,577) is a selective antagonist of tachykinin NK1 receptor, also is an allosteric enhancer with micromolar potency at muscarinic M3 receptor, also is a highly efficacious inhibitor of main protease (Mpro) of SARS-CoV-2.

物理化学性质&存储条件

分子量 437.59
分子式 C29H31N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3R,4S,7S,8R,11S,12R)-8-ethynyl-3,7-dimethyl-18,20,27-triazaheptacyclo[15.11.0.03,15.04,12.07,11.019,27.021,26]octacosa-1(28),15,17,19,21,23,25-heptaen-8-ol

参考文献

1. Briejer MR, et al. Eur J Pharmacol. 1993 Nov 30;250(1):181-3.

2. Lazareno S, et al. J Mol Neurosci. 2003;20(3):363-7.

3. Singh A, et al. Biochemistry. 2025 Jan 30. doi: 10.1021/acs.biochem.4c00535.

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