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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-WIKI4
WIKI4

Chemical Structure : WIKI4

CAS No.: 838818-26-1

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WIKI4 (WIKI-4)

货号: PC-45086Not For Human Use, Lab Use Only.

WIKI4 is a novel small molecule inhibitor of the Wnt/β-catenin pathway by inhibiting the enzymatic activity of TNKS2.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

WIKI4 is a novel small molecule inhibitor of the Wnt/β-catenin pathway by inhibiting the enzymatic activity of TNKS2, prevents auto-ADP-ribosylation of TNKS2 with IC50 of 15 nM.
WIKI4  inhibits expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling in cancer cell lines as well as in human embryonic stem cells.

物理化学性质&存储条件

分子量 521.5896
分子式 C29H23N5O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 6.8 mg/mL
Chemical Name/SMILES

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[3-[[4-(4-methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-

参考文献

1. James RG, et al. PLoS One. 2012;7(12):e50457.

2. Haikarainen T, et al. PLoS One. 2013 Jun 6;8(6):e65404.

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