WHN-88 | Porcupine inhibitor | Probechem Biochemicals

Chemical Structure : WHN-88

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WHN-88 (WHN88)

货号: PC-20098Not For Human Use, Lab Use Only.

WHN-88 is a potent, selective Porcupine (PORCN) inhibitor, inhibits Wnt/β-catenin signaling with IC50 of ST-Luc of 0.02 uM.

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生物&药学活性

WHN-88 is a potent, selective Porcupine (PORCN) inhibitor, inhibits Wnt/β-catenin signaling with IC50 of ST-Luc of 0.02 uM.
WHN-88 effectively abolished palmitoylation of Wnt ligands and prevented their secretion and the subsequent Wnt/β-catenin signaling transduction.
WHN-88 remarkably suppressed the spontaneous occurrence and growth of MMTV-Wnt1 murine breast tumors.
WHN-88 also notably restrained the progress of xenografted Wnt-driven human tumors, including PA-1 teratocarcinoma with high autocrine Wnt signaling and Aspc-1 pancreatic carcinoma with Wnt-sensitizing RNF43 mutation.
WHN-88 inhibited cancer cell stemness obviously.

物理化学性质&存储条件

分子量	557.13
分子式	C18H13I2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3,5-diiodo-4-oxopyridin-1(4H)-yl)-N-(5-phenylpyridin-2-yl) acetamide

参考文献

1. Yang Q, et al. Eur J Pharmacol. 2023 Feb 28;945:175628.

WHN-88 (WHN88)

生物&药学活性

物理化学性质&存储条件

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WHN-88 (WHN88)

生物&药学活性

物理化学性质&存储条件

参考文献

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