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首页-小分子抑制剂&激动剂-Others-Other Targets-WGU55
WGU55

Chemical Structure : WGU55

CAS No.:

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WGU55 ((H)Phe- Bip -Asp- Arg -Kbt)

货号: PC-26184Not For Human Use, Lab Use Only.

WGU55 is a potent, selective peptidomimetic TMPRSS6 inhibitor with Ki of 12.15 nM and IC50 of 138 nM in TMPRSS6-transfected HEK293 cells, shows >200-fold selectivity over matriptase, Factor Xa and Thrombin.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

WGU55 is a potent, selective peptidomimetic TMPRSS6 inhibitor with Ki of 12.15 nM and IC50 of 138 nM in TMPRSS6-transfected HEK293 cells, shows >200-fold selectivity over matriptase, Factor Xa and Thrombin.

物理化学性质&存储条件

分子量 761.90
分子式 C41H43N7O6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-3-((S)-3-([1,1'-biphenyl]-4-yl)-2-(3-phenylpropanamido)propanamido)-4-(((S)-1-(benzo[d]thiazol-2-yl)-5-guanidino-1-oxopentan-2-yl)amino)-4-oxobutanoic acid

参考文献

1. Walid Guerrab, et al. J Med Chem. 2025 Dec 25;68(24):26012-26029.

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