WEHI-9625 | BAK inhibitor | Probechem Biochemicals

Chemical Structure : WEHI-9625

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WEHI-9625 (WEHI9625)

货号: PC-73094Not For Human Use, Lab Use Only.

WEHI-9625 (WEHI9625) is a small molecule selectively binds to VDAC2 and promotes its ability to inhibits apoptosis (EC50=69 nM) driven by murine BAK, selectively blocks murine BAK-mediated apoptosis.

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生物&药学活性

WEHI-9625 (WEHI9625) is a small molecule selectively binds to VDAC2 and promotes its ability to inhibits apoptosis (EC50=69 nM) driven by murine BAK, selectively blocks murine BAK-mediated apoptosis.
VDAC2, but not VDAC1 or VDAC3, is essential for WEHI-9625 and its analogs to block BAK-mediated apoptosis.
WEHI-9625 acts by enhancing the VDAC2-BAK interaction.
WEHI-9625 blocks apoptosis before mitochondrial damage, preserving cellular function and long-term clonogenic potential.

物理化学性质&存储条件

分子量	593.712
分子式	C34H27NO5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(2-(4-Methoxybenzoyl)phenyl)-N-(4-methylbenzyl)-4H-thieno[3,2-c]thiochromene-2-carboxamide 5,5-dioxide

参考文献

1. van Delft MF, et al. Nat Chem Biol. 2019 Nov;15(11):1057-1066.

WEHI-9625 (WEHI9625)

生物&药学活性

物理化学性质&存储条件

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WEHI-9625 (WEHI9625)

生物&药学活性

物理化学性质&存储条件

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