WEHI-7326 | Mitotic inhibitor | Probechem Biochemicals

Chemical Structure : WEHI-7326

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WEHI-7326 (WEHI 7326)

货号: PC-72413Not For Human Use, Lab Use Only.

WEHI-7326 (WEHI 7326) is a specific mitotic inhibitor and potential anticancer agent, causes cell cycle arrest in G2/M, cell death in vitro (MDA-MB-231 IC50=24.4 nM), and displays efficacious anti-tumor activity in vivo.

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生物&药学活性

WEHI-7326 (WEHI 7326) is a specific mitotic inhibitor and potential anticancer agent, causes cell cycle arrest in G2/M, cell death in vitro (MDA-MB-231 IC50=24.4 nM), and displays efficacious anti-tumor activity in vivo.
WEHI-7326 induces cell death in a broad range of cancer cell lines, including taxane-resistant cells, and inhibits growth of human colon, brain, lung, prostate and breast tumors in mice xenografts.
WEHI-7326 exceeded potency of myoseverin B by almost ten-fold, did not show any significant cytotoxic activity in vitro (IC50>40 uM) in HepG2 cells.
WEHI-7326 prolongs survival in mouse models of high-risk neuroblastoma and leads to complete tumor regression when used in combination with standard-of-care relapse therapies.

物理化学性质&存储条件

分子量	463.502
分子式	C22H25N9O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((4-((4-(aminomethyl)benzyl)amino)-6-((4-methoxybenzyl)amino)-1,3,5-triazin-2-yl)amino)imidazolidine-2,4-dione

参考文献

1. Christoph Grohmann, et al. Cell Death Dis. 2021 Mar 12;12(3):268.

WEHI-7326 (WEHI 7326)

生物&药学活性

物理化学性质&存储条件

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WEHI-7326 (WEHI 7326)

生物&药学活性

物理化学性质&存储条件

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