WEHI-345 |CAS:1354825-58-3 Probechem Biochemicals

Chemical Structure : WEHI-345

CAS No.: 1354825-58-3

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WEHI-345 (WEHI 345,WEHI345)

货号: PC-45564Not For Human Use, Lab Use Only.

WEHI-345 is a potent and selective RIPK2 inhibitor with IC50/Kd of 130/46 nM.

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5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
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生物&药学活性

WEHI-345 is a potent and selective RIPK2 inhibitor with IC50/Kd of 130/46 nM.
WEHI-345 displays negligible activity (>10 uM) against RIPK1, RIPK4 and RIPK5.
WEHI-345 delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement.
WEHI-345 prevents cytokine production in vitro and in vivo and ameliorates experimental autoimmune encephalomyelitis in mice.

物理化学性质&存储条件

分子量	401.4643
分子式	C22H23N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	4-Pyridinecarboxamide, N-[2-[4-amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]-

参考文献

1. Nachbur U, et al. Nat Commun. 2015 Mar 17;6:6442.

WEHI-345 (WEHI 345,WEHI345)

生物&药学活性

物理化学性质&存储条件

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WEHI-345 (WEHI 345,WEHI345)

生物&药学活性

物理化学性质&存储条件

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