欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-WEHI-092
WEHI-092

Chemical Structure : WEHI-092

CAS No.: 883494-13-1

加入收藏

WEHI-092 (WEHI092)

货号: PC-26500Not For Human Use, Lab Use Only.

WEHI-092 is a potent and selective inhibitor of USP9X with IC50 of 254 nM, directly binds to USP9X catalytic domain with SPR KD of 1 uM, does not inhibit USP24 and other DUBs.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

WEHI-092 is a potent and selective inhibitor of USP9X with IC50 of 254 nM, directly binds to USP9X catalytic domain with SPR KD of 1 uM, does not inhibit USP24 and other DUBs.
Incubation of the USP9X catalytic domain with 50 µM WEHI-092 inhibited cleavage of K48-linked di-ubiquitin and prevented the modification of USP9X with ubiquitin propargylamide (Ub-PA), a suicide substrate that covalently modifies the catalytic Cys1566 of USP9X.
WEHI-092 (50 uM) does not affect any of 49 human DUBs with the exception of USP9X.
WEHI-092 binds within the Fingers subdomain of USP9X.
WEHI-092 is cytotoxic in a small subset of cancer cell lines, destabilises the centrosomal protein CEP55 with IC50 of 1.3 uM.
WEHI-092 is non-lethal and non-toxic to the non-cancerous human cell lines studied (HUVECs and HDFs).
WEHI-092 (10 uM) caused 50% cell growth inhibition, including stalling cell growth completely in MOLT-4 and SK-MEL-2 cells.
WEHI-092 (10 uM) also led to reduced protein levels of CEP55, MKRN2, CEP131 and PCM1, in MDA-MB-231 cells.
WEHI-092 caused arrested mitosis in MDA-MB-231, MiaPaca2, and SK-MEL-2 cells.

物理化学性质&存储条件

分子量 455.53
分子式 C23H25N3O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)piperazin-1-yl)(2,3-dimethyl-1H-indol-5-yl)methanone

参考文献

1. Schenk P, et al. Global analysis of cancer cell responses to USP9X inhibition. EMBO J. 2026 Apr 7. doi: 10.1038/s44318-026-00742-y.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: