WDR5 WIN site inhibitor C6 TFA

Chemical Structure : WDR5 WIN site inhibitor C6 TFA

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货号: PC-22311Not For Human Use, Lab Use Only.

WDR5 inhibitor C6 TFA is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM.

规格	价格	库存	数量
10 mg		Get quote
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

WDR5 inhibitor C6 TFA is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM.
WDR5 inhibitor C6 inhibits cell lines and primary transformed cells carrying MLL1 rearrangements (MV4:11, IC50=3.2 uM), induces apoptosis and kills cells in a p53-dependent manner.
WDR5 inhibitor C6 rapidly displace WDR5 from chromatin and decrease the expression of associated genes, causing translational inhibition, nucleolar stress, and p53 induction.

物理化学性质&存储条件

分子量	612.41
分子式	C27H23Cl2F4N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[(3,4-dichlorophenyl)methyl]-3-[(2,3-dihydro-2-imino-3-methyl-1H-imidazol-1-yl)methyl]-5-(6-fluoro-2-methyl-3-pyridinyl)-, 2,2,2-trifluoroacetate (1:1)

参考文献

1. Aho ER, et al. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.